Mega Man Zero 4, known in Japan as Rockman Zero 4 (ロックマンゼロ4, Rokkuman Zero Fō), is a video game developed by Inti Creates and Natsume and published in 2005 by Capcom for the Game Boy Advance (GBA) handheld. It is the fourth and final title in the Mega Man Zero subseries of the Mega Man franchise and is set several months after the events of Mega Man Zero 3. The game deals with Dr. Weil’s reign over Neo Arcadia in which humans, who have been reduced to second-rate citizens, begin to escape in large numbers to the last-known livable location on the planet, Area Zero, beginning a conflict between the two groups. The effects of this war eventually drive Zero and the Resistance to protect Area Zero and its inhabitants from Dr. Weil.

Mega Man Zero 4 has an average of 77% on Metacritic and GameRankings, making it roughly the 85th best-ranking Game Boy Advance title.